Stimulation and inhibition of rat oocyte meiosis by forskolin
نویسندگان
چکیده
منابع مشابه
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Adenylyl cyclase (AC) isoforms 1 to 9 are differentially expressed in tissues and constitute an interesting drug target. ACs 1 to 8 are activated by the diterpene, forskolin (FS). It is unfortunate that there is a paucity of AC isoform-selective activators. To develop such compounds, an understanding of the structure/activity relationships of diterpenes is necessary. Therefore, we examined the ...
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Progression through the meiotic cell cycle must be strictly regulated in oocytes to generate viable embryos and offspring. During mitosis, the kinesin motor protein Kif4 is indispensable for chromosome condensation and separation, midzone formation and cytokinesis. Additionally, the bioactivity of Kif4 is dependent on phosphorylation via Aurora Kinase B and Cdk1, which regulate Kif4 function th...
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ژورنال
عنوان ژورنال: Biology of Reproduction
سال: 1984
ISSN: 0006-3363,1529-7268
DOI: 10.1095/biolreprod30.3.537